Multiphase modeling of tumor growth with matrix remodeling and fibrosis
نویسندگان
چکیده
We present a multiphase mathematical model for tumor growth which incorporates the remodeling of the extracellular matrix and describes the formation of fibrotic tissue by tumor cells. We also detail a full qualitative analysis of the spatially homogeneous problem, and study the equilibria of the system in order to characterize the conditions under which fibrosis may occur.
منابع مشابه
Multiphase modeling of tumor growth and extracellular matrix interaction: Mathematical tools and applications
In a multiphase modeling framework tumors are described as a mixture of tumor and host cells within a porous structure constituted by a remodeling extracellular matrix (ECM), which is wet by a physiological extracellular fluid. The main focus of the model presented in this article is the description of the mechanical interactions of the growing tumor with the host tissue, their influence on tum...
متن کاملTGF-ß1 Latency Associated Peptide Promotes Remodeling of Healing Cutaneous Wounds in the Rat
Background: The process of wound healing involves integrated events including inflammation, granulation tissue formation, matrix deposition and remodeling. Growth factors play a key role in the process. Among them transforming growth factor-ß1 (TGF-ß1) is known to accelerate tissue repair by promoting the synthesis and deposition of extracellular matrix proteins. However, persistence or overact...
متن کاملInvestigating the CTGF mRNA Expression Level in Patients with Colorectal Cancer
Background: The Connective Tissue Growth Factor (CTGF) gene encoding an extracellular matrix (ECM)-associated protein and as a member of the CCN family of proteins plays a major role in fibrosis, inflammation and connective tissue remodeling in a variety of diseases including cancer. The CCN proteins are multifunctional and are involved in cell proliferation, adhesion and cell development durin...
متن کاملTumor growth modeling from the perspective of multiphase porous media mechanics.
Multiphase porous media mechanics is used for modeling tumor growth, using governing equations obtained via the thermodynamically constrained averaging theory (TCAT). This approach incorporates the interaction of more phases than legacy tumor growth models. The tumor is treated as a multiphase system composed of an extracellular matrix, tumor cells which may become necrotic depending on nutrien...
متن کاملBeneficial effects of N-acetylcysteine on protease-antiprotease balance in attenuating bleomycin-induced pulmonary fibrosis in rats
Objective(s): The role of N-acetylcysteine (NAC) as an anti-oxidant in attenuating bleomycin-induced pulmonary fibrosis has been reported. However, its effect on parenchymal remodeling via regulating the protease-antiprotease balance is not fully defined. Therefore, the present study was designed to explore the possible role of matrix metalloproteinases (MMP), tissue i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Mathematical and Computer Modelling
دوره 52 شماره
صفحات -
تاریخ انتشار 2010